NUCLEIC ACID LIGANDS TO LL37

摘要

The present invention is directed to nucleic acid ligands to LL37, methods for producing said nucleic acid ligands, and methods for utilizing said nucleic acid ligands. In one exemplary embodiment, for example, this invention relates to nucleic acid ligands exhibiting high specific binding affinity to LL37 peptides, precursors and/or portions thereof. Further, the nucleic acid ligands may bind competitively with native ligands of LL37 and may also inhibit and/or interfere with LL37 function, such as by binding to LL37.

主权项

1. A composition comprising:
at least one modified aptamer having a specific binding affinity to human LL37, said at least one modified aptamer comprising at least one higher-order-bond modified nucleobase; wherein said specific binding affinity substantially inhibits the function of said human LL37.