发明名称 |
COMPOSITIONS, METHODS AND USES FOR DENGUE VIRUS SEROTYPE-4 CONSTRUCTS |
摘要 |
Embodiments herein report compositions, methods and uses for dengue-4 (DENV-4) virus constructs. Some embodiments concern a composition that includes, but is not limited to, DENV-4 virus constructs alone or in combination with other constructs, can be used in a vaccine composition to induce an immune response in a subject. In certain embodiments, compositions can include constructs of more than one serotypes of dengue virus, such as dengue-1 virus, dengue-2 virus, or dengue-3 virus in combination with DENV-4 virus constructs disclosed herein. In other embodiments, DENV-4 constructs disclosed herein can be combined in a composition with other flavivirus constructs to generate a vaccine against more than one flavivirus. Other embodiments provide methods and uses for DENV-4 virus constructs in vaccine compositions that when administered to a subject induce an immune response in the subject against DENV-4 that is improved by modified constructs compared to other vaccine compositions. |
申请公布号 |
EP2916864(A1) |
申请公布日期 |
2015.09.16 |
申请号 |
EP20130795387 |
申请日期 |
2013.11.08 |
申请人 |
TAKEDA VACCINES, INC.;THE GOVERNMENT OF THE UNITED STATES OF AMERICA ASREPRESENTED BY THE SECRETARY OF THE DEPARTMENT OFHEALTH AND HUMAN SERVICES |
发明人 |
LIVENGOOD, JILL A.;KINNEY, CLAIRE;POWELL, TIMOTHY D.;STINCHCOMB, DAN T.;OSORIO, JORGE |
分类号 |
A61K39/12 |
主分类号 |
A61K39/12 |
代理机构 |
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代理人 |
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主权项 |
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