| 摘要 |
本发明之一种态样的一个具体例为用于减轻包含忧郁症；双极性障碍；焦虑症；强迫症；物质滥用障碍；与创伤和压力相关的异常；以及破坏性、冲动控制及行为规范障碍症之心理及行为异常的症状的方法，包括投药治疗有效量之胆硷性M1受体拮抗剂以及治疗有效量之一种或多种之拟胆硷作用剂以减轻该等心理及行为异常的症状。典型地，该胆硷性M1受体拮抗剂系选自替仑西平、阿米替林、吡哌立登、三己芬迪、达非那新、待克明以及噻托溴铵所组成群组。本发明之另一态样系关于应用其他治疗剂与用于仿效非选择性mAChR拮抗剂东莨菪硷的理论上药理效果的治疗剂的组合的方法与组成物。本发明也涵括并入一种或多种之治疗剂与医药可接受载剂之医药组成物。; bipolar disorders; anxiety disorders; obsessive-compulsive disorders; substance use disorder; trauma- and stressor-related disorders; and disruptive, impulsive-control, and conduct disorders comprising the step of administering a therapeutically effective quantity of a cholinergic M1 receptor antagonist and a therapeutically effective quantity of one or more cholinomimetic agents to lessen the symptoms of such mental and behavioral disorders. Typically, the cholinergic M1 receptor antagonist is selected from the group consisting of telenzepine, amytriptyline, biperiden, trihexyphenidyl, darifenacin, dicyclomine, and tiotropium. Another aspect of the present invention is directed to methods and compositions employing other therapeutic agents and combinations of therapeutic agents for emulating the theoretical pharmacological effects of the non-selective mAChR antagonist scopolamine. The invention also encompasses pharmaceutical compositions incorporating one or more therapeutic agents and a pharmaceutically acceptable carrier. |
