发明名称 |
COMPOSITIONS FOR ENHANCING TRANSPORT AND ANTISENSE EFFICACY OF NUCLEIC ACID ANALOG INTO CELLS |
摘要 |
Compositions and methods for enhancing delivery of molecules, e.g. biologica l agents, into cells are described. The composition is a conjugate of the biological agent, preferably a nucleic acid analog having a substantially uncharged backbone, covalently linked to a peptide transporter moiety as described. Conjugation of the peptide transporter to a substantially uncharg ed nucleic acid analog, such as a morpholino oligomer, is also shown to enhance binding of the oligomer to its target sequence and enhance antisense activit y. |
申请公布号 |
CA2523672(A1) |
申请公布日期 |
2004.11.11 |
申请号 |
CA20042523672 |
申请日期 |
2004.04.29 |
申请人 |
AVI BIOPHARMA, INC. |
发明人 |
IVERSEN, PATRICK L.;MOULTON, HONG M.;NELSON, MICHELLE H.;KROEKER, ANDREW D.;STEIN, DAVID A. |
分类号 |
A61K47/48;A61K31/7088;A61K47/42;A61K49/00;C07K17/00;C12N15/113 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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