发明名称 |
SULFOXIMINE SUBSTITUTED QUINAZOLINES FOR PHARMACEUTICAL COMPOSITIONS |
摘要 |
This invention relates to novel sulfoximine substituted quinazoline derivatives of formula I wherein Ar, R1 and R2 are as defined herein, and their use as MNK1 (MNK1a or MNK1b) and/or MNK2 (MNK2a or MNK2b) kinase inhibitors, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment or amelioration of MNK1 (MNK1a or MNK1b) and/or MNK2 (MNK2a or MNK2b) mediated disorders. |
申请公布号 |
EP2917185(A1) |
申请公布日期 |
2015.09.16 |
申请号 |
EP20130785876 |
申请日期 |
2013.11.04 |
申请人 |
BOEHRINGER INGELHEIM INTERNATIONAL GMBH |
发明人 |
BLUM, MARTIN;GOTTSCHLING, DIRK;HECKEL, ARMIN;HEHN, JOERG;LEHMANN, THORSTEN;WIEDENMAYER, DIETER |
分类号 |
C07D239/94;A61K31/47;A61P35/00 |
主分类号 |
C07D239/94 |
代理机构 |
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代理人 |
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