发明名称 |
Pharmaceutical formulations comprising nitrocatechol derivatives and methods of making thereof |
摘要 |
The present disclosure relates to compositions and pharmaceutical formulations comprising at least one active pharmaceutical ingredient chosen from nitrocatechol derivatives of formula I as defined herein and salts, esters, hydrates, solvates and derivatives thereof and methods of making said compositions and pharmaceutical formulations. |
申请公布号 |
US9132094(B2) |
申请公布日期 |
2015.09.15 |
申请号 |
US201012750956 |
申请日期 |
2010.03.31 |
申请人 |
BIAL—Portela & Ca, S.A. |
发明人 |
Cardoso de Vasconcelos Teófilo;Jorge dos Santos Lima Ricardo;Cerdeira de Campos Costa Rui |
分类号 |
A01N43/40;A61K31/44;C07D413/04;C07D413/14;A61K9/48;A61K9/16;A61K31/4245;A61K31/4439;A61K45/06 |
主分类号 |
A01N43/40 |
代理机构 |
The Marbury Law Group, PLLC |
代理人 |
The Marbury Law Group, PLLC |
主权项 |
1. A composition comprising at least one active pharmaceutical ingredient chosen from 2,5-dichloro-3-(5-(3,4-dihydroxy-5-nitrophenyl)-1,2,4-oxadiazol-3-yl)-4,6-dimethylpyridine 1-oxide, at least one phosphate derivative, and at least one polyvinylpyrrolidone derivative compound;
wherein said at least one active pharmaceutical ingredient is present in the composition in granular form and wherein the bulk density of the composition is greater than 0.2 g/mL. |
地址 |
Sao Mamede do Coronado PT |