Dihydropyrazole GPR40 modulators

摘要

The present invention provides compounds of Formula (I):;
or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are GPR40 G protein-coupled receptor modulators which may be used as medicaments.

主权项

1. A compound of Formula (I):or a stereoisomer, a tautomer, or a pharmaceutically acceptable salt thereof, wherein:
R1 is independently phenyl substituted with 0-3 R6 or pyridinyl substituted with 0-3 R6; R2 is, at each occurrence, independently halogen or C1-4 alkyl; R3 is independently selected from: CF3, 4-halo-Ph, 4-CN-Ph, 4-CO2(C1-2 alkyl)-Ph, 2-halo-4-CN-Ph, and pyrimidin-2-yl; R4 is independently C1-4 alkyl or cyclopropylmethyl; R5 is, at each occurrence, independently halogen; and R6, at each occurrence, is independently selected from: OH, halogen, CN, C1-4 alkyl, and C1-4 alkoxy.