Medical devices and methods comprising an adhesive sheet containing a drug depot

摘要

Improved medical devices and methods are provided that are implantable at or near a target tissue site beneath the skin of a patient, the medical device comprises an adhesive sheet having a region configured to receive a drug depot, the drug depot disposed within the region of the adhesive sheet and the drug depot having at least one surface configured to release a therapeutically effective amount of the drug over a period of at least one day, wherein the adhesive sheet limits movement of the medical device at or near the target tissue site. In some embodiments, the medical device provided can include an effective amount of at least one analgesic and/or at least one anti-inflammatory agent at or near a target site, and can reduce, prevent or treat inflammation and/or pain, particularly postoperative pain or orthopedic degenerative pathology pain.

主权项

1. A medical device implantable at or near a target tissue site beneath the skin of a patient, the medical device comprising a sheet having a region including one or more channels, holes, grooves or slits configured to receive a drug depot, the drug depot including loops, hooks, eyelets, barbs, posts, tabs and/or clips corresponding to the one or more channels, holes grooves or slits of the region such that the drug depot lies fixed within the region of the sheet prior to implantation of the medical device, the drug depot having at least one surface configured to release a therapeutically effective amount of the drug over a period of at least one day, wherein the sheet comprises adhesive on at least one surface thereof, the adhesive being spaced apart from the drug depot and configured to limit movement of the drug depot at or near the target tissue site upon contact with tissue and wherein the sheet and the drug depot are biodegradable and the drug depot degrades slower than the sheet.