Use of Slurp1 as an imunomodulatory molecule in the ocular surface

摘要

Methods for treating inflammation are disclosed, such as for treating ocular inflammation. In some embodiments, the ocular inflammation is inflammation of an ocular surface, such as keratitis. The methods include administering to a subject with inflammation a therapeutically effective amount of SLURP1, or a nucleic acid encoding SLURP1, thereby treating the inflammation.

主权项

1. A method for treating keratitis in a subject, comprising
selecting a subject with keratitis, and administering locally to the cornea of the subject a therapeutically effective amount of a nucleic acid encoding the SLURP1 polypeptide operably linked to a regulatory sequence, wherein the SLURP1 polypeptide comprises an amino acid sequence at least 95% identical to the amino acid sequence set forth as amino acids 23-103 of SEQ ID NO: 1, wherein the SLURP1 polypeptide is expressed in the cornea, thereby treating the keratitis subject.