DETECTING INCREASE OR DECREASE IN THE AMOUNT OF A NUCLEIC ACID HAVING A SEQUENCE OF INTEREST

摘要

A method of detecting copy number variations in foetal or tumour DNA within a sample of circulating cell-free DNA includes carrying out amplification of DNA such that amplification of longer DNA molecules is discriminated against. This results in preferential amplification of foetal or tumour DNA, which can then be analysed using, for example,array comparative genome hybridisation.