发明名称 |
CASPASE POLYPEPTIDES HAVING MODIFIED ACTIVITY AND USES THEREOF |
摘要 |
The technology relates in part to compositions comprising modified caspase-9 polypeptides, compositions comprising nucleic acids coding for modified caspase-9 polypeptides, chimeric modified caspase-9 polypeptides, and methods of use thereof, including methods for cell therapy. Methods for cell therapy include modifying transfused cells to express an inducible modified caspase-9 protein, with reduced basal activity in the absence of the inducer. |
申请公布号 |
CA2940460(A1) |
申请公布日期 |
2015.09.11 |
申请号 |
CA20152940460 |
申请日期 |
2015.03.06 |
申请人 |
BELLICUM PHARMACEUTICALS, INC. |
发明人 |
SPENCER, DAVID;CHANG, WEI-CHUN;SLAWIN, KEVIN |
分类号 |
C12N5/16;A61P7/00;A61P37/06;C07K19/00 |
主分类号 |
C12N5/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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