发明名称 Novel Pyrazole Derivative
摘要 Provided is a novel therapeutic means for Alzheimer's disease.;In particular, provided is a compound represented by the following general formula (I):;;or a salt thereof.
申请公布号 US2015252029(A1) 申请公布日期 2015.09.10
申请号 US201314434185 申请日期 2013.09.17
申请人 Green Tech Co., Ltd. 发明人 Sugimoto Hachiro;Okuda Michiaki;Nakayama Shinichi;Inoue Yoshikazu;Sakata Yoko;Fujita Yuki;Tokizane Rie
分类号 C07D405/14;C07D401/14;C07D231/12;C07D403/10;C07D405/10 主分类号 C07D405/14
代理机构 代理人
主权项 1. A compound represented by the following general formula (I): [wherein R1 represents a hydrogen atom, a halogen atom, a hydroxy group, a nitro group, an amino group, a cyano group, a C1-6 alkyl group optionally having one or more substituents, a C1-6 alkoxy group optionally having one or more substituents, a mono- or di(C1-6 alkyl)amino group optionally having one or more substituents, a C1-6 alkylthio group optionally having one or more substituents, a C1-6 alkylsulfonyl group optionally having one or more substituents, a C1-6 acyl group optionally having one or more substituents, a C1-6 acylamino group optionally having one or more substituents, a C2-6 alkenyl group optionally having one or more substituents, a C2-6 alkenyloxy group optionally having one or more substituents, a mono- or di(C2-6 alkenyl)amino group optionally having one or more substituents, a C2-6 alkenylthio group optionally having one or more substituents, or a carbamoyl group optionally having one or more substituents; R2 represents a group represented by the following general formula (II): (wherein m and n each represent an integer of 0 or 1, A represents —O—, —NH—, —S—, —SO— or —SO2—, Y represents a C1-6 alkylene group, a C2-6 alkenylene group or a C2-6 alkynylene group, and R3 represents a nitrogen-containing heterocyclic group optionally having one or more substituents, a C1-6 alkoxy group optionally having one or more substituents, a mono- or di(C1-6 alkyl)amino group optionally having one or more substituents, a mono- or di(C2-6 alkenyl)amino group optionally having one or more substituents, or a carbamoyl group optionally having one or more substituents); R1 and R2 may be joined to form a ring together with the benzene ring; and Ar represents a homocyclic or heterocyclic group optionally having one or more substituents], or a salt thereof.
地址 Mie JP