Degradable Nanogel for Drug Delivery

摘要

A nano-sized hydrogel is made of a water-soluble chain containing carboxylic acid moieties and polyethylene side chains. Such a nanogel is applicable as a cancer-drug delivery agent or an imagining agent, where either a cancer drug, such as cisplatin, or an imaging agent, such as Gd3+. The complexation of the cancer drug or the imaging agent with the carboxyl moieties leads to the hydrogel formation.

主权项

1. A core-shell structured nanogel, comprising:
(a) a graft-copolymer comprising a water-soluble backbone chain comprised of carboxylic acid moieties and grafted PEG side chains attached to said water-soluble backbone said polymeric compound having the generic structure (b) a therapeutic agent complexed with the carboxylic acid moieties; and (c) wherein the carboxylic moieties of the graft-copolymer complexed with the therapeutic agent forms the core of the nanogel and the PEG chains form the shell of the nanogel.