METHOD OF PREDICTING SEVERITY OF DEPRESSIVE DISORDERS IN MEN WITH ISCHEMIC HEART DISEASE

摘要

FIELD: medicine.SUBSTANCE: invention relates to field of medicine, namely to method of predicting depression of severe degree in men with ischemic heart disease (IHD). Essence of method consists in the fact that time and structure connection between IHD and signs of depression are determined in men with IHD, level of personal anxiety is measured by Spielberg-Khanin test. If level of personal anxiety is lower than 45 points polymorphisms -1438A/G in gene of serotonin receptor of 2A type and Val66Met gene of neurotrophic brain factor are determined, after which depression of severe degree is predicted in patients who are carriers of allele S of polymorphism 5-HTTLPR, allele G of polymorphism -1438A/G and genotype ValVal of polymorphism Val66Met.EFFECT: application of claimed method makes it possible to efficiently detect patients with high risk of developing severe degree of depression and administer differentiated psychopharmacotherapy to them in due time.7 ex