摘要 |
FIELD: medicine, pharmaceutics.SUBSTANCE: invention describes analogues of 5-(tetradecyloxy)-2-furoic acid (TOFA) of formula, where Rrepresents -O-R, Rindependently represents heterocyclylalkyl or halogenalkyl; or Rrepresents -O-R-C(O)N(R)R, each Rrepresents alkylene chain and Rrepresents optionally substituted alkyl or optionally substituted phenyl, each Rindependently represents hydrogen, alkyl or cycloalkyl and each Rrepresents alkyl, cycloalkyl, benzyl or -R-C(O)OR; or any Rand Rtogether with nitrogen atom, which they are both bound to, form optionally substituted N-heterocyclyl, or its pharmaceutically acceptable salts.EFFECT: invention relates to pharmaceutical compositions for treatment of dermatological disorders or conditions, characterised by hyperactivity of sebaceous glands, such as acne and greasy skin, and other dermatological disorders and conditions, containing TOFA analogues and pharmaceutically acceptable excipient for dermatological or peroral introduction.24 cl, 3 dwg, 6 tbl, 33 ex |