ANTI-PROLACTIN RECEPTOR ANTIBODY FORMULATIONS

摘要

Provided are a wide concentration range, especially high concentration, substantially salt-free anti-prolactin receptor antibody formulations that are substantially isosmotic and of low viscosity.

主权项

1. An anti-PRLR antibody formulation, comprising:
a. 0 mM to 70 mM histidine; b. 50 ppm to 300 ppm of a non-ionic surfactant; c. 34 mM to 292 mM of a sugar selected from mannitol, dextrose, glucose, trehalose, and sucrose; d. 0 mM to 50 mM arginine; e. 0 mM to 50 mM lysine; f. 0 mM to 270 mM glycine or alanine; g. 0 mM to 10 mM methionine; and h. 1 mg/ml to 150 mg/ml of an anti-PRLR antibody; wherein said anti-PRLR antibody formulation has a pH ranging from pH 5.0 to pH 6.5.