| 主权项 |
1. A compound, or a pharmaceutically acceptable salt thereof, having the structure of Formula AA or Formula AB:wherein:
“HetD” is a heteroaryl moiety comprising from 5 to 7-ring atoms and from 1 to 3 heteroatoms which are independently for each occurrence sulfur or nitrogen, and which may be optionally substituted with alkyl, aryl, heteroaryl, aralkyl, alkylaryl, aralkenyl, heteroaralkyl, alkylheteroaryl, heteroaralkenyl, hydroxyl, hydroxyalkyl, alkoxy, aryloxy, aralkoxy, acyl, aroyl, halo, nitro, cyano, carboxy, alkoxycarbonyl, aryloxycarbonyl, aralkoxycarbonyl, alkylsulfonyl, arylsulfonyl, heteroarylsulfonyl, alkylsulfinyl, arylsulfinyl, heteroarylsulfinyl, alkylthio, arylthio, heteroarylthio, aralkylthio, heteroaralkylthio, cycloalkyl, cycloalkenyl, heterocyclyl, heterocyclenyl, R60R65N—, R60R65N-alkyl-, R60R65NC(O)— and R60 R65NSO2—, wherein R60 and R65 are each independently: hydrogen, alkyl, aryl, and aralkyl; one of “RA1” or “RA2” is —H and the other is, independently: —H; C1-4 alkyl; halogen; RB1 is —H or C1-6 alkyl which is optionally substituted with: C1-20 alkyl; halogen; -alkoxy; —OH; —CN; alkylthio-; amino, —NH(linear or branched alkyl), —NH(cycloalkyl), —N(alkyl)2, —(C═O)—OH; —C(O)O-alkyl; S(alkyl); or —S(O2)-alkyl; or -aryl; cycloalkyl, each of which optional substituent may itself be substituted with: alkyl, aryl, heteroaryl, aralkyl, alkylaryl, aralkenyl, heteroaralkyl, alkylheteroaryl, heteroaralkenyl, hydroxy (also termed “hydroxyl” when standing alone as a substituent moiety), hydroxyalkyl, alkoxy, aryloxy, aralkoxy, acyl, aroyl, halo, nitro, cyano, carboxy, alkoxycarbonyl, aryloxycarbonyl, aralkoxycarbonyl, alkylsulfonyl, arylsulfonyl, heteroarylsulfonyl, alkylsulfinyl, arylsulfinyl, heteroarylsulfinyl, alkylthio, arylthio, heteroarylthio, aralkylthio, heteroaralkylthio, cycloalkyl, cycloalkenyl, heterocyclyl, heterocyclenyl, R60R65N—, R60R65N-alkyl-, R60R65NC(O)— and R60R65NSO2—, wherein R60 and R65 are each independently: hydrogen, alkyl, aryl, and aralkyl; and RC is:
(A) a substituent of the formula: wherein RD is optionally 1 to 3 substituents which are independently:
(i) I or Cl;(ii) amino-alkenyl moiety of the formula [H2N—(CH2)n—CH═CH—], where “n” is an integer of 1 to 4;(iii) heterocycloalkyl of the formula: wherein: “n” and “m” are independently 1 to 4; and “Ri” is C1-4-alkyl or —H;(iv) a moiety of the formula:wherein “m” is 1-4;
(v) an aryl moiety which is substituted with a dialkylamino-C1-3-alkyl-NH—C(O)-moiety;(vi) a heterobicyclo-moiety of the formula: (vii) a substituent of the formula:which is optionally substituted with one or more moieties which are, independently: halogen or C1-4-alkyl;
(viii) C1-6-alkyl moiety, which is optionally substituted with C1-20 alkyl; halogen; -alkoxy; —OH; —CN; alkylthio-; amino, —NH(linear or branched alkyl), —NH(cycloalkyl), —N(alkyl)2, —(C═O)—OH; —C(O)O-alkyl; S(alkyl); or —S(O2)-alkyl; or -aryl; cycloalkyl, each of which optional substituent may itself be substituted with: alkyl, aryl, heteroaryl, aralkyl, alkylaryl, aralkenyl, heteroaralkyl, alkylheteroaryl, heteroaralkenyl, hydroxy (also termed “hydroxyl” when standing alone as a substituent moiety), hydroxyalkyl, alkoxy, aryloxy, aralkoxy, acyl, aroyl, halo, nitro, cyano, carboxy, alkoxycarbonyl, aryloxycarbonyl, aralkoxycarbonyl, alkylsulfonyl, arylsulfonyl, heteroarylsulfonyl, alkylsulfinyl, arylsulfinyl, heteroarylsulfinyl, alkylthio, arylthio, heteroarylthio, aralkylthio, heteroaralkylthio, cycloalkyl, cycloalkenyl, heterocyclyl, heterocyclenyl, R60R65N—, R60R65N-alkyl-, R60R65NC(O)— and R60R65NSO2—, wherein R60 and R65 are each independently: hydrogen, alkyl, aryl;(ix) C1-6-alkoxy which is optionally substituted with C1-20 alkyl; halogen; -alkoxy; —OH; —CN; alkylthio-; amino, —NH(linear or branched alkyl), —NH(cycloalkyl), —N(alkyl)2, —(C═O)—OH; —C(O)O-alkyl; S(alkyl); or —S(O2)-alkyl; or -aryl; cycloalkyl, each of which optional substituent may itself be substituted with: alkyl, aryl, heteroaryl, aralkyl, alkylaryl, aralkenyl, heteroaralkyl, alkylheteroaryl, heteroaralkenyl, hydroxy (also termed “hydroxyl” when standing alone as a substituent moiety), hydroxyalkyl, alkoxy, aryloxy, aralkoxy, acyl, aroyl, halo, nitro, cyano, carboxy, alkoxycarbonyl, aryloxycarbonyl, aralkoxycarbonyl, alkylsulfonyl, arylsulfonyl, heteroarylsulfonyl, alkylsulfinyl, arylsulfinyl, heteroarylsulfinyl, alkylthio, arylthio, heteroarylthio, aralkylthio, heteroaralkylthio, cycloalkyl, cycloalkenyl, heterocyclyl, heterocyclenyl, R60R65N—, R60R65N-alkyl-, R60R65NC(O)— and R60R65NSO2—, wherein R60 and R65 are each independently: hydrogen, alkyl, aryl, and aralkyl;(x) —CN; or(xi) C1-4-alkynyl moiety which is optionally substituted with C1-20 alkyl; halogen; -alkoxy; —OH; —CN; alkylthio-; amino, —NH(linear or branched alkyl), —NH(cycloalkyl), —N(alkyl)2, —(C═O)—OH; —C(O)O-alkyl; S(alkyl); or —S(O2)-alkyl; or -aryl; cycloalkyl, each of which optional substituent may itself be substituted with: alkyl, aryl, heteroaryl, aralkyl, alkylaryl, aralkenyl, heteroaralkyl, alkylheteroaryl, heteroaralkenyl, hydroxy (also termed “hydroxyl” when standing alone as a substituent moiety), hydroxyalkyl, alkoxy, aryloxy, aralkoxy, acyl, aroyl, halo, nitro, cyano, carboxy, alkoxycarbonyl, aryloxycarbonyl, aralkoxycarbonyl, alkylsulfonyl, arylsulfonyl, heteroarylsulfonyl, alkylsulfinyl, arylsulfinyl, heteroarylsulfinyl, alkylthio, arylthio, heteroarylthio, aralkylthio, heteroaralkylthio, cycloalkyl, cycloalkenyl, heterocyclyl, heterocyclenyl, R60R65N—, R60R65N-alkyl-, R60R65NC(O)— and R60R65NSO2—, wherein R60 and R65 are each independently: hydrogen, alkyl, aryl, and aralkyl;(B) a substituent of the formula:which is optionally substituted with one or more moieties which are, independently: halogen or C1-4-alkyl; or
(C) a substituent of the formula: wherein n is an integer of from 0 to 3 and RE is: (i) —N(Ri)2, where Ri is independently —H or —C1-6-alkyl, optionally substituted with —CN, OH, or -alkoxy. |
