摘要 |
PROBLEM TO BE SOLVED: To provide a method for producing or modifying a protein, particularly an antibody.SOLUTION: The invention relates to a gene structure in which at least any genes and a drug resistance gene are arranged between two site-specific recombination enzyme target sequences, where the target sequence of a site-specific recombination enzyme, any genes, a drug resistance gene, and the target sequence of a site-specific target recombinant enzyme are arranged in order from the upstream side of the gene structure, and only the drug resistance gene is arranged to the opposite direction. |