发明名称 2-amino-3-(imidazol-2-yl)-pyridin-4-one derivatives and their use as VEGF receptor kinase inhibitors
摘要 The invention relates to the compounds of general formula (I): Preparation process and therapeutic use.;
申请公布号 US9126972(B2) 申请公布日期 2015.09.08
申请号 US201214117750 申请日期 2012.05.16
申请人 SANOFI 发明人 Braun Alain;Duclos Olivier;Lassalle Gilbert;Lorge Franz;Martin Valerie;Ritzeler Olaf;Strub Aurelie
分类号 C07D471/04;C07D401/14;C07D401/04;A61K31/4709;A61K31/4375;A61K45/06 主分类号 C07D471/04
代理机构 Morrison & Foerster LLP 代理人 Morrison & Foerster LLP
主权项 1. A compound of formula (I): in which: W represents a nitrogen atom or a group CH;Y represents a group C2-C3-alkynylene or a 1,4-phenylene optionally substituted with R7 which represents one or more halogen atom(s);Z represents a bond or a group CR1R2;R1 and R2, independently of each other, represent a group chosen from a hydrogen atom, a group C1-C6-alkyl, a trifluoromethyl group, a group (CH2)nOR6, C3-C7-cycloalkyl, an heteroaryl or an aryl optionally substituted with one or more halogen atom(s);or R1 and R2 can form together, with the carbon atom which bear them, a C3-C7-cycloalkyl;R3 represents a hydrogen atom;R4 represents a group chosen from a group C1-C6-alkyl, a group (CH2)nOR6, C3-C7-cycloalkyl or C1-C6-alkyl optionally substituted by a C3-C7-cycloalkyl;R5 represents a group chosen from a hydrogen atom or a group C1-C6-alkyl;R6 represents a group chosen from a hydrogen atom or a group C1-C6-alkyl;n is equal to 1, 2 or 3; in the form of the base or of an acid-addition salt.
地址 Paris FR