发明名称 Linear polyesteramides from aminophenolic esters
摘要 The present invention is directed to linear, biodegradable polyesteramide (PEA) polymers synthesized with repeating units derived from aminophenol esters and diacids. These PEAs have a monomer repeat represented by; as well as a variety of uses to coat, form or comprise medical devices, combination medical devices and pharmaceutical compositions, including sustained release formulations.
申请公布号 US9127124(B2) 申请公布日期 2015.09.08
申请号 US201414491102 申请日期 2014.09.19
申请人 TYRX, INC. 发明人 Schwartz Arthur;Pulapura Satish;Nethula Sarita;Rajaram Archana;Moses Arikha
分类号 C08G69/44;A61K9/00;A61K31/09;A61K31/4465;A61K31/496;A61K31/65;A61K31/7036;A61L29/06;A61L29/08;A61L31/06;A61L31/10;C08L77/12;C08L101/00;C08G69/00;A61K47/34;A61L29/14;A61L29/16;A61L31/14;A61L31/16;A61M25/00 主分类号 C08G69/44
代理机构 Sorell, Lenna & Schmidt, LLP 代理人 Sorell, Lenna & Schmidt, LLP
主权项 1. A synthetic polymer comprising monomer units represented by the formula: wherein R is —(CR3R4)a— or —CR3.═CR4—; R1 is hydrogen; saturated or unsaturated alkyl, aryl, alkylaryl or alkyl ether having from 1 to 20 carbon atoms; or —(R5)qO((CR3R4)rO)s—R6; each R2 is independently a divalent, linear or branched, substituted or unsubstituted alkylene, alkenylene, alkynylene, arylene, alkylarylene, divalent alkyl ether or aryl ether moiety having from 1 to 30 carbon atoms; —(R5)qO((CR3R4)rO)s(R5)q—; or —(R5)qCO2((CR3R4)rO)sCO(R5)q—; R3 and R4 are each independently, hydrogen or linear or branched, substituted or unsubstituted alkyl having from 1 to 10 carbon atoms, R5 is independently linear or branched lower alkylene or lower alkenylene; R6 is independently linear or branched, substituted or unsubstituted, saturated or unsaturated lower alkyl; the aromatic ring has from zero to four Z1 substituents, each of which is independently selected from the group consisting of halide, lower alkyl, alkoxy, nitro, alkyl ether, a protected hydroxyl group, a protected amino group and a protected carboxylic acid group; Y is (bc)n, b is c is n is a number of repeat units; a is 0 to 10; each q is independently 1 to 4; each r is independently 1 to 4; and each s is independently 1 to 5000.
地址 Monmouth Junction NJ US