Method of treatment using substituted pyrazolo[1,5-a] pyrimidine compounds

摘要

Compounds useful in the synthesis of compounds for treating pain, cancer, inflammation, neurodegenerative disease or Typanosoma cruzi infection in a mammal.

主权项

1. A compound of Formula (I): or a pharmaceutically acceptable salt thereof, wherein: R1 is H or (1-6C alkyl); R2 is NRbRc; NRbRc forms a 5-6 membered heterocyclic ring having a ring heteroatom which is nitrogen and optionally having a second ring heteroatom or group selected from N, O and SO2, wherein the heterocyclic ring formed by NRbRc is optionally substituted with one or two substituents independently selected from OH, F, NH2, CO2H, CO2Et, NHCO2C(CH3)3, CF3, methyl, ethyl, isopropyl, CO2C(CH3)3 and oxo; Y is phenyl optionally substituted with one or more substituents independently selected from halogen, (1-4C)alkoxy, CF3 and CHF2; X is —CH2—; R3 is H or (1-4C alkyl); each R4 is independently selected from halogen, (1-4C)alkyl, OH, (1-4C)alkoxy, NH2, NH(1-4C alkyl) and CH2OH; and n is 0, 1, or 2.