Methods of making and using surfactant polymers

摘要

Comblike, surfactant polymers for changing the surface properties of biomaterials are provided. Such surfactant polymers comprise a polymeric backbone of repeating monomeric units having functional groups for coupling with side chains, a plurality of hydrophobic side chains linked to the backbone via the functional groups, and a plurality of hydrophilic side chains linked to said backbone via the functional groups. Medical devices coated with the surfactant polymers are also provided. The surfactant polymers may be used to decrease the thrombogenic properties, encapsulation, and bacterial colonization of medical devices.

主权项

1. A method for preparing a surfactant polymer, the method comprising the following steps:
a) providing a polymer comprising a plurality of side groups selected from the group consisting of hydroxyl groups, carboxyl groups, and primary amine groups; b) providing:
i) an alkanoyl or alkanal comprising 2 to 18 methylene groups including an end group that is reactable with a first side group of the polymer; andii) a hydrophilic compound selected from the group consisting of oligosaccharide chains including an end group that is reactable with a second side group of the polymer, and oligopeptides including an end group that is reactable with the second side group of the polymer; and c) reacting the polymer with the alkanoyl or alkanal compound and the hydrophilic compound in an anhydrous solvent to yield the surfactant polymer having a molar percentage yield of at least 50 percent and a ratio of hydrophilic to hydrophobic side chains of about 1:4.3 to about 1:6.5.