| 主权项 |
1. A recombinant insect whose genome comprises a dominant lethal genetic system with a conditional lethal effect, the system comprising:
(i) a lethal gene under the control of a promoter, wherein the lethal gene is present in the system regardless of sex of the insect, (ii) a transactivator gene, which expresses a repressible transactivator protein and is under the control of sex-specific promoter; and (iii) a binding sequence for the repressible transactivator protein, wherein the lethal effect of the system is sex-specific, and expression of the lethal gene is activatable by the repressible transactivator protein which is repressible by a tetracycline, tetracycline analogue, or tetracycline derivative, wherein the lethal effect of the genetic system is repressible by the tetracycline, analogue, or derivative, and wherein the insect is a mosquito, medfly or pink bollworm. |
