| 发明名称 |
TETRAHYDRO- AND DIHYDRO-ISOQUINOLINE PRMT5 INHIBITORS AND USES THEREOF |
| 摘要 |
Described herein are compounds of Formula (A), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT5 activity. Methods of using the compounds for treating PRMT5 mediated disorders are also described. |
| 申请公布号 |
PH12015501351(A1) |
申请公布日期 |
2015.09.07 |
| 申请号 |
PH12015501351 |
申请日期 |
2015.06.15 |
| 申请人 |
EPIZYME, INC. |
发明人 |
DUNCAN, KENNETH, W;CHESWORTH, RICHARD;BORIACK-SJODIN, PAULA ANN;MUNCHHOF, MICHAEL, JOHN;JIN, LEI |
| 分类号 |
A61K31/472;A61K31/4725;A61P3/04;A61P3/10;A61P7/06;A61P35/00;C07D217/12;C07D401/12;C07D405/12 |
主分类号 |
A61K31/472 |
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