RISK ASSESSMENT FOR ANTIBIOTICS TREATMENT IN PATIENTS SUFFERING FROM PRIMARY NON-INFECTIOUS DISEASE BY DETERMINING THE LEVEL OF PROCALCITONIN

摘要

A diagnostic method for the identification of a subject suffering from a primary non-infectious disease having an increased risk of an adverse outcome potentially being induced by the administration of an antibiotic to said subject comprising the determination of the level of Procalcitonin (PCT) or a fragment thereof or a precursor or fragment thereof having a length of at least 12 amino acid residues in a sample of a bodily fluid from said subject and the correlation of the determined level to a potential risk induced by the administration of an antibiotic, as well as a kit for performing the method and methods of treatment based thereon.

主权项

1. A method for diagnosing whether a subject suffering from a primary non-infectious disease has an increased risk of an adverse outcome potentially being induced by administration of an antibiotic in order to treat or prevent potential bacterial infections to said subject, comprising:
(a) detecting and quantifying in a sample of a bodily fluid from the subject the level of Procalcitonin (PCT) or a fragment thereof having an amino acid sequence 2-116 or 3-116 of the PCT of SEQ ID NO:1, wherein said detection and quantitation comprises
(i) contacting said sample with a diagnostic assay capture molecule which specifically binds to the PCT or fragment thereof and(ii) quantitating the capture molecule:PCT or fragment thereof complex, and thereby determining the level of PCT or fragment thereof in the sample; (b) comparing the thus-determined level of PCT or fragment thereof in the sample with a predetermined value for the prediction of a potential risk induced by the administration of an antibiotic.