发明名称 |
Methods Of Producing A Secreted Protein |
摘要 |
The invention is directed to methods of producing a polypeptide or a variant thereof, wherein the polypeptide or variant thereof is dependent on LIMP-2 for trafficking, localization, stabilization and/or sorting of the polypeptide in the cell. In general, the methods comprise culturing a lysosomal integral membrane protein II (LIMP-2) deficient cell which expresses the polypeptide or the variant thereof under conditions in which the polypeptide or the variant thereof is produced. |
申请公布号 |
US2015246960(A1) |
申请公布日期 |
2015.09.03 |
申请号 |
US201514593904 |
申请日期 |
2015.01.09 |
申请人 |
Genzyme Corporation ;Biochemical Institute |
发明人 |
Reczek David J.;Saftig Paul;DeMaria Christine T. |
分类号 |
C07K14/705 |
主分类号 |
C07K14/705 |
代理机构 |
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代理人 |
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主权项 |
1. A nucleic acid molecule comprising SEQ ID NO: 1. |
地址 |
Cambridge MA US |