发明名称 |
CO-EXPRESSION OF MAGNETOTACTIC BACTERIAL GENES AND GENES ENCODING IRON HANDLING PROTEINS IN CELLS |
摘要 |
The invention provides an improved modified magnetosome that contains more iron therein with the combination of the expressed genes. This is achieved by co-expression of (a) one or more bacterial magnetotactic genes to amplify iron uptake, compartmentalization and biomineralization in cells, with (b) one or more mammalian iron handling proteins that together augment(s) and/or regulate the cells iron pool. As a result, mammalian cells or bacterial cells that are transfected or transformed, respectively, can be more effectively tracked using various imaging technologies. |
申请公布号 |
WO2015127527(A1) |
申请公布日期 |
2015.09.03 |
申请号 |
WO2014CA00555 |
申请日期 |
2014.07.08 |
申请人 |
LAWSON HEALTH RESEARCH INSTITUTE |
发明人 |
GOLDHAWK, DONNA E.;KOROPATNICK, D. JAMES;FIGUEREDO, RENE;PRATO, FRANK S.;THOMPSON, R. TERRY;GELMAN, NEIL |
分类号 |
C12N15/63;A61K49/00;C12N1/21;C12N5/10;C12N15/31;C12N15/85;C12Q1/68 |
主分类号 |
C12N15/63 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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