PROCESS FOR PREPARATION AND PURIFICATION OF RECOMBINANT HUMAN ONCOSTATIN M PROTEIN

摘要

The invention relates to a process for cloning gene of human mature OSM protein; producing the culture of recombinant bacterial strain and expressing the polypeptide into inclusion bodies. The invention also provides a method for fermentation process. The invention also relates to a process for isolating and purifying said protein from insoluble fraction of bacterial strain by subjecting the material to chromatography. Recovered protein is formulated for stability.˙