发明名称 |
AFFINITY PEPTIDE-MODIFIED PARTICLES AND TARGETED DRUG DELIVERY METHODS |
摘要 |
A therapeutic particle comprises a particle comprising one or more therapeutic agents and one or more fibrin-avid peptide variants attached to the surface of the particle. A method for magnetically targeting a therapeutic agent toward a device in a subject, such as a temporarily introduced magnetizable catheter or an implanted stent, comprises administering the therapeutic particles to the subject and generating a magnetic field, which targets the magnetic particles toward the device. The affinity peptide-modified therapeutic particles may comprise an effective amount of an anti-proliferative agent, such as paclitaxel, to inhibit or prevent in-stent restenosis. |
申请公布号 |
EP2911702(A1) |
申请公布日期 |
2015.09.02 |
申请号 |
EP20130848459 |
申请日期 |
2013.10.25 |
申请人 |
THE CHILDREN'S HOSPITAL OF PHILADELPHIA |
发明人 |
LEVY, ROBERT, J.;CHORNY, MICHAEL |
分类号 |
A61K47/48;A61K9/00;A61K31/337;A61K41/00 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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