Volatile distillate by-product of mint oil that promotes absorption and/or bioavailability of compounds of bio-medical and nutritional interest

摘要

Disclosed is an adjuvant for improving the bioavailability of bioactive compositions. The adjuvant is prepared from a byproduct of mint flavor production. In vitro and in vivo testing confirms effectiveness. The adjuvant contains a mixture of compounds which is effective to improve the oral bioavailability of a bioactive composition normally having limited absorptivity, and it comprises a mixture of nonpolar compounds and compounds with some polar characteristics. In preferred form the nonpolar compounds comprise compounds selected from a group that includes terpene hydrocarbons and terpene derivatives and the compounds with some polar characteristics comprise compounds selected from a group that includes aldehydes, alcohols and ketones. The preferred compositions will have a ratio of nonpolar compounds and compounds with some polar characteristics is within the range of from 5:1 to 20:1. The adjuvants can enhance delivery of CoQ10 and other bioactive compositions, such as carotenoids (e.g., β-carotene), curcuminoids, lycopene, resveratrol, flavonoids and other phenolic compounds, organosulfur compounds, saponins, sterols, stanols, and mixtures of at least two of these, to the interior cellular environment, including organelles, such as the mitochondria.

主权项

1. A composition comprising CoQ10 and an adjuvant mixture wherein the adjuvant mixture is present in an amount effective to improve the oral bioavailability of Coenzyme Q10 (CoQ10), said adjuvant mixture prepared from a volatile distillate byproduct fractions of mint derived from an extracted essential oil fraction of mint and wherein the adjuvant mixture comprises a mixture of nonpolar compounds and compounds with some polar characteristics at ratio within the range of from 5:1 to 20:1, and comprises less than 10% limonene, less than 5% of any of menthol, menthone, menthofuran and menthyl acetate, and less than 1% of any of pulegone, and germacrene D.