发明名称 |
Dry powder formulations and methods for treating pulmonary diseases |
摘要 |
The present invention is directed toward respirable dry particles for delivery of divalent metal cation salts and/or monovalent cation salts to the respiratory tract and methods for treating a subject having a respiratory disease and/or infection. |
申请公布号 |
US9119778(B2) |
申请公布日期 |
2015.09.01 |
申请号 |
US201514667857 |
申请日期 |
2015.03.25 |
申请人 |
Pulmatrix Operating Company, Inc. |
发明人 |
Sung Jean C.;Lipp Michael M. |
分类号 |
A61K9/14;A61P31/00;A61P11/00;A61K33/14;A61K31/19;A61K9/00;A61M15/00;A61K47/18;A61K31/194 |
主分类号 |
A61K9/14 |
代理机构 |
McDermott Will & Emery LLP |
代理人 |
McDermott Will & Emery LLP |
主权项 |
1. A respirable dry powder comprising respirable dry particles that comprise a divalent metal cation salt, wherein the divalent metal cation salt provides divalent metal cation in an amount of about 5% or more by weight of the dry particle, and the respirable dry particles that comprise a divalent metal cation salt have a volume median geometric diameter (VMGD) of about 5 microns or less, a tap density of greater than 0.4 g/cubic centimeter (cc) and are further characterized by a capsule emitted powder mass (CEPM) of at least 80% when emitted from a passive dry powder inhaler that has a resistance of about 0.036 sqrt(kPa)/liters per minute (LPM) under the following conditions: an inhalation energy of 1.15 Joules at a flow rate of 30 LPM using a size 3 capsule that contains a total mass of 25 mg, said total mass consisting of the respirable dry particles that comprise a divalent metal cation salt, and wherein the VMGD of the dry particles emitted from the inhaler is 5 microns or less. |
地址 |
Lexington MA US |