Tablet quickly disintegrating in the oral cavity and method for producing the same

摘要

The present invention relates to a tablet which is rapidly disintegrated in an oral cavity containing an active ingredient at a high content and a production method thereof. That is, the present invention provides a tablet which is rapidly disintegrated in an oral cavity containing an active ingredient in not less than 25% of the total weight, having a disintegration time of within 40 seconds and an absolute hardness of 1.8 N/mm2 or more, which is obtained by granulating a powder containing an active ingredient with a binding solution containing mannitol and corn-derived pregelatinized starch, mixing the resulting granules with at least one kind of a disintegrant selected from cornstarch, hydroxypropylstarch, carmellose and crospovidone, and compression molding the mixture.

主权项

1. A tablet, which is rapidly disintegrated in an oral cavity, comprising (a) an active ingredient selected from the group consisting of acetaminophen, ibuprofen, indomethacin, ethenzamide, droxidopa, levodopa, amoxicillin, cefalexin, erythromycin, and clarithromycin in not less than 25% of the total weight, (b) mannitol, (c) corn-derived pregelatinized starch, and (d) at least one disintegrant selected from the group consisting of cornstarch, hydroxypropylstarch, carmellose and crospovidone, wherein the tablet is obtained by compression molding of a mixture comprising a granule obtainable by granulating a powder comprising the active ingredient with a binding solution comprising mannitol and corn-derived pregelatinized starch, and at least one disintegrant.