Oral liquid compositions of rhein or diacerein

摘要

The invention relates to liquid pharmaceutical compositions for oral administration comprising rhein or diacerein, or salts or esters or prodrugs thereof and processes for preparing such compositions.

主权项

1. A pharmaceutical composition in the form of dry syrups or solid ready mix comprising:Sr. No.Ingredients% Composition1.Diacerein0.5-3.75%2.Poloxamer0.01-0.5%3.Magnesium aluminium silicate0.25-10%4.Acesulfame0.1-5%5.Colloidal silicon dioxide0.1-5%6.Sodium benzoate0.01-157.Sodium citrate0.01-1%8.Flavours0.01-5%9.Sucroseq.s, wherein said composition exhibits a dissolution profile such that more than 75% of diacerein is released within 30 minutes, wherein the release profile is measured in Apparatus 2 (USP, Dissolution, paddle, 75 rpm) using 1000 ml of pH 5.7 phosphate buffer at 37° C.±0.5° C.; and, wherein said composition results in a reduction of undesirable effects of soft stools.