| 发明名称 |
INHIBITORS OF BETA-SECRETASE |
| 摘要 |
The present invention relates to spirocyclic acylguanidines and their use as inhibitors of the β-secretase enzyme (BACE1) activity, pharmaceutical compositions containing the same, and methods of using the same as therapeutic agents in the treatment of neurodegenerative disorders, disorders characterized by cognitive decline, cognitive impairment, dementia and diseases characterized by production of β-amyloid aggregates. |
| 申请公布号 |
US2015239849(A1) |
申请公布日期 |
2015.08.27 |
| 申请号 |
US201514662553 |
申请日期 |
2015.03.19 |
| 申请人 |
Vitae Pharmaceuticals, Inc. ;Boehringer Ingelheim International GMBH |
发明人 |
Bukhtiyarov Yuri;Cacatian Salvacion;Dillard Lawrence Wayne;Fuchs Klaus;Jia Lanqi;Lala Deepak S.;Morales-Ramos Angel;Singh Suresh B.;Venkatraman Shankar;Xu Zhenrong;Yuan Jing;Zhao Yi;Zheng Yajun;Dorner-Ciossek Cornelia;Gross Ulrike;Heine Niklas;Sauer Achim |
| 分类号 |
C07D235/02;C07D403/04;C07D403/06;C07C255/59;C07D401/06;C07C313/06;C07C49/747;C07D405/06;C07D401/14 |
主分类号 |
C07D235/02 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
Fort Washington PA US |
