发明名称 |
ENGINEERED MONOMERIC ANTIBODY FRAGMENTS |
摘要 |
<p>The present invention relates to monomeric polypeptides comprising an engineered monomeric antibody fragment (e.g., monomeric Fc-containing polypeptides) wherein the monomeric Fc comprises one or more engineered N-linked glycosylation sites in the CH3-CH3 dimerization interface. Methods for producing such engineered monomeric antibody fragments and their use in diagnostics and therapeutics are also provided.</p> |
申请公布号 |
WO2014087299(A9) |
申请公布日期 |
2015.08.27 |
申请号 |
WO2013IB60384 |
申请日期 |
2013.11.25 |
申请人 |
PFIZER INC. |
发明人 |
DUAN, WEILI;KRIZ, RONALD, W.;TETSUYA, ISHINO |
分类号 |
C07K16/00 |
主分类号 |
C07K16/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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