发明名称 |
NOVEL POLYSACCHARIDE AND USES THEREOF |
摘要 |
Provided herein is a novel E. coli O polysaccharide, O25B. Also provided herein are prokaryotic host cells comprising enzymes (e.g., glycosyltransferases) used in O25B production. The host cells provided herein produce 025B bioconjugates, wherein said bioconjugates comprise O25B linked to a carrier protein. Further provided herein are compositions, e.g., pharmaceutical compositions, comprising O25B and/or bioconjugates comprising O25B. Such compositions can be used as vaccines against infection with ExPEC, and may further comprise one or more additional bioconjugates. |
申请公布号 |
CA2940547(A1) |
申请公布日期 |
2015.08.27 |
申请号 |
CA20152940547 |
申请日期 |
2015.02.23 |
申请人 |
GLYCOVAXYN AG |
发明人 |
KOWARIK, MICHAEL T.;WETTER, MICHAEL L.;KEMMLER, STEFAN J.;HAUPTLE, MICHA A.;GAMBILLARA, VERONICA;MALLY, MANUELA |
分类号 |
C12N1/21;A61K39/108;A61K39/385;A61P31/04;A61P37/04;C07K2/00;C07K14/195;C07K14/21;C07K14/245;C12N1/20;C12N9/00;C12N9/10;C12N15/52;C12P19/04;C12P21/00 |
主分类号 |
C12N1/21 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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