| 发明名称 |
PHARMACEUTICAL COMPOSITIONS CONTAINING POLYPEPTIDES DERIVED FROM ALPHA-1 ANTITRYPSIN AND METHODS OF USE THEREOF |
| 摘要 |
The present invention relates to isolated polypeptides comprising the amino acid sequence of residues 378-413 of Mus musculus α-1-antitrypsyn (serpina1c), and active fragments thereof, and to pharmaceutical compositions comprising same. The compositions of the invention are useful for treating burns, inflammatory, autoimmune and degenerative diseases. |
| 申请公布号 |
US2015239955(A1) |
申请公布日期 |
2015.08.27 |
| 申请号 |
US201514628644 |
申请日期 |
2015.02.23 |
| 申请人 |
YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM, LTD. |
发明人 |
WORMSER Uri |
| 分类号 |
C07K14/81 |
主分类号 |
C07K14/81 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A composition comprising an isolated polypeptide, wherein said composition is pharmaceutically acceptable, said polypeptide diminishes or abrogates an inflammatory response in a subject and said polypeptide shares at least 95% identity with a polypeptide consisting of an amino acid sequence selected from the group consisting of SEQ ID NO:1, SEQ ID NO:2, SEQ ID NO: 3 and SEQ ID NO: 4. |
| 地址 |
Jerusalem IL |
