主权项 |
1. A calcium channel blocker selected from the group consisting:
of calcium channel blockers of the phenylalkylamine family of formula I and salts thereof, in which: the R1, R2 and R3 groups are identical or different and are selected from phenyl and fluorophenyl radicals, provided that at least one of the R1, R2 and R3 groups is a fluorophenyl radical; of calcium channel blockers of the amino acid family of formula II,
H2N—CH2—C(R4)R′4—CH2—COOR5 Formula II in which: the R4 group is a linear- or branched-chain lower alkyl radical containing up to eight carbon atoms and the R′4 group is a hydrogen atom, or R4 and R′4 together form a cyclic lower alkyl radical containing up to eight carbon atoms, and the R5 group is a hydrogen atom or a linear- or branched-chain lower alkyl radical containing up to eight carbon atoms; of calcium channel blockers of the benzofuran family of formula III and salts thereof, in which: the R6 group represents a linear- or branched-chain lower alkyl radical containing up to six carbon atoms, the R7 group represents a hydrogen atom or a methyl group, the N(R8)R′8 group represents a dimethylamino, diethylamino, dipropylamino, piperidino, pyrrolidino or morpholino group, and the Y and Y1 groups are identical and represent a hydrogen, iodine or bromine atom; for use thereof in the treatment of a motor neuronopathy selected from spinal muscular atrophy, amyotrophic lateral sclerosis, primary lateral sclerosis, Kennedy's disease and Charcot-Marie-Tooth disease. |