| 主权项 |
1. A method of treating a disease selected from the group consisting of type 1 diabetes, type 2 diabetes, metabolic syndrome, atherosclerosis, dyslipidaemia, mitochondrial disorders, sarcopenia, obesity, hypertension, cerebral ischemia, cognitive defect, Alzheimer's disease, Parkinson's disease, Huntington's disease, schizophrenia, Friedrich's Ataxia, amyotrophic lateral sclerosis, multiple sclerosis, neuroinflammation, inflammatory pain, neuropathic pain, epilepsy, HIV, cytomegalovirus, hepatitis C virus, and cancer, which method comprises administering to a subject in need thereof a therapeutically effective amount of a compound of formula (I) or a pharmaceutically acceptable salt thereof: wherein: R1 is
a) a 5-membered heteroaryl optionally substituted with 1, 2, or 3 groups independently selected from —CH3, —OCH3, —OH, —CH2OH, —CF3, —OCF3, —CN, —CO2H, —CH2CO2H, —CONH2, —NH2 and halogen;b) O-phenyl optionally substituted with a group selected from methyl, methoxy, fluoro, and CO2H;c) selected from the group consisting of H, CO2H, CO2Et, and NO2;d) phenyl optionally substituted with a group selected from CO2H, Cl, F, methyl, —CN, —NMe2 and methoxy;e) selected from the group consisting of 3-pyridinyl, 4-pyridinyl, and —S(O)— phenyl; orf) selected from the group consisting of O-pyridin-2-yl, O-(4-methyl-pyridin-2-yl), O-(5-methoxy-pyridin-2-yl) and O-(5-methyl-pyridin-2-yl); n=0 or 2; R2 is H; wherein * designates point of attachment; R4 is Cl; R5 is H; and R7 is H and R6 is selected from a group consisting of, —NHMe, —NMe2, —NHC(O)OMe, —OMe, —OEt, Et, iPr, —CH2OH, and —CH2CH2OH or is a group selected from wherein * designates point of attachment; or R6 and R7 taken together form a group selected from wherein * designates point of attachment; orwherein:
i) R1=3-methoxyphenyl, R4 is F and R3=4-(4-morpholino)phenyl; ii) R1=3-methylisoxazol-5-yl, and R3=3-dimethylaminophenyl; or iii) R1=3-methoxyphenyl, and R3=3-dimethylaminophenyl; provided the compound is not 7-chloro-4-hydroxy-3-(3-methyl-1H-pyrazol-1-yl)-6-(4-(pyrrolidin-1-yl)phenyl)quinolin-2(1H)-one, 7-chloro-4-hydroxy-3-(2-methylthiazol-4-yl)-6-(4-(piperidin-1-yl)phenyl)quinolin-2(1H)-one, 7-chloro-6-(4-(dimethylamino)phenyl)-4-hydroxy-3-(5-methylisoxazol-3-yl)quinolin-2(1H)-one, 7-chloro-6-(4-(dimethylamino)phenyl)-3-(2,5-dimethylthiazol-4-yl)-4-hydroxyquinolin-2(1H)-one or 7-chloro-4-hydroxy-6-(3′-methoxy-[1,1′-biphenyl]-4-yl)-3-(1H-pyrazol-1-yl)quinolin-2(1H)-one. |
