| 主权项 |
1. A cross-linked material comprising:
multivalent cross-linking agents that bind an exogenous target molecule; and conjugates that include a drug and two or more separate affinity ligands bound to a conjugate framework, wherein the two or more affinity ligands compete with the exogenous target molecule for binding with the cross-linking agents and wherein conjugates are cross-linked within the material as a result of non-covalent interactions between cross-linking agents and affinity ligands on different conjugates, wherein the conjugate is of the general formula: wherein: each occurrence of represents a potential branch within the conjugate; each occurrence of represents a potential branch within the conjugate; each occurrence of is independently a covalent bond, a carbon atom, a heteroatom, or an optionally substituted group selected from the group consisting of acyl, aliphatic, heteroaliphatic, aryl, heteroaryl, and heterocyclic; each occurrence of T is independently a covalent bond or a bivalent, straight or branched, saturated or unsaturated, optionally substituted C1-30 hydrocarbon chain wherein one or more methylene units of T are optionally and independently replaced by —O—, —S—, —N(R)—, —C(O)—, —C(O)O—, —OC(O)—, —N(R)C(O)—, —C(O)N(R)—, —S(O)—, —S(O)2—, —N(R)SO2—, —SO2N(R)—, a heterocyclic group, an aryl group, or a heteroaryl group; each occurrence of R is independently hydrogen, a suitable protecting group, or an acyl moiety, arylalkyl moiety, aliphatic moiety, aryl moiety, heteroaryl moiety, or heteroaliphatic moiety; —B is-T-LB-X; each occurrence of X is independently an affinity ligand; each occurrence of LB is independently a covalent bond or a group derived from the covalent conjugation of a T with an X; -D is -T-LD-W; each occurrence of W is independently a drug; each occurrence of LD is independently a covalent bond or a group derived from the covalent conjugation of a T with a W; k is an integer from 2 to 1 I, inclusive, defining at least two k-branches within the conjugate; q is an integer from 1 to 4, inclusive; k+q is an integer from 3 to 12, inclusive; each occurrence of p is independently an integer from 1 to 5, inclusive; and each occurrence of n is independently an integer from 0 to 5, inclusive; and each occurrence of m is independently an integer from 1 to 5, inclusive; and each occurrence of v is independently an integer from 0 to 5, inclusive, with the proviso that within each k-branch at least one occurrence of n is ≧1 and at least one occurrence of v is ≧1. |
