Method for solubilising, dispersing and stabilising of substances, products manufactured according to the method as well as the use thereof

摘要

Disclosed is a method in which poloxamer, a resin, and/or a tocopherol is/are fused, and the material that is to be treated is intimately dispersed with said melt. After being introduced into the melt, the material that is to be treated is coated with water to prevent hardening, and the spontaneously forming gel is homogenized. The obtained product is composed of a transparent gel that is based on at least one poloxamer, a resin or a tocopherol, and an active substance which is solubilized, dispersed, and stabilized therein and whose consistency ranges from solid, semisolid, i.e. aspic-like, to liquid. The micelles of said solubilized matter remain stable even when the same is diluted well below the CMC of poloxamer.

主权项

1. A stabilized product comprising a transparent gel that comprises at least one polyoxyethylene-polyoxypropylene block copolymer (poloxamer), a natural or an artificially prepared resin and/or a tocopherol, and an active agent, said active agent being one or more substance selected from the group consisting of insulin, cyclosporine, polyphenyl compounds, propolis, selenium dioxide, tar, mineral oil, plant extracts from holy thistle, plant extracts from passion flower, plant extracts from butterbur, silymarin, and chrysin; said stabilized product being formed by (a) melting said at least one poloxamer and said resin and/or said tocopherol together at an elevated temperature to form a molten liquid mass, (b) solubilizing or dispersing the active agent within said molten liquid mass without addition of water, and (c) then covering the molten liquid mass containing solubilized or dispersed active agent with water having a temperature at about said elevated temperature, thereby forming said transparent gel which contains micelles that retain and/or bind the active agent, wherein said micelles have a diameter less than 80 nanometers and are stable in water when diluted below critical micelle concentration of the poloxamer.