Heteroarylcarboxylic acid ester derivative

摘要

Compounds represented by formula (I):;
wherein each symbol is as defined in the description, and pharmaceutically acceptable salts thereof are useful as hyperglycemic inhibitors having a serine protease inhibitory action and as prophylactic or therapeutic drugs for diabetes.

主权项

1. A method for the prophylaxis or treatment of type II diabetes or hyperglycemia, comprising administering an effective amount of a compound represented by formula (I): wherein R1, R2, R3, and R4 may be the same or different and are each independently a hydrogen atom, a nitro group, a halogeno group, a cyano group, a hydroxyl group, a thiol group, an amino group, a guanidino group, a formyl group, a lower alkyl group, a lower alkenyl group, a lower alkynyl group, a lower acyl group, a carboxyl group, a sulfo group, a phosphono group, a lower alkoxyl group, a lower alkylthio group, a lower alkylamino group, a lower acyloxy group, a lower acylamino group, a lower alkoxycarbonyl group, a carbamoyl group, a lower alkylcarbamoyl group, a lower alkylsulfonylamino group, or a sulfamoyl group; HetAr is a furan ring optionally having substituent(s); X is a lower alkylene group optionally having substituent(s), a lower alkenylene group optionally having substituent(s), a lower alkynylene group optionally having substituent(s), or a thiophenylene group; Y is a carbonyl group, a thiocarbonyl group, or a sulfonyl group; and A is a group of formula (II): wherein R6 and R7 may be the same or different and are each independently a hydrogen atom, a hydroxyl group, a lower alkyl group optionally having substituent(s), a lower alkenyl group optionally having substituent(s), a lower alkynyl group optionally having substituent(s), or a lower alkoxyl group optionally having substituent(s), or R6 and R7 may be bonded to form a cyclic amino group optionally having substituent(s), or a pharmaceutically acceptable salt thereof, to a subject in need thereof.