Modulation of nerves innervating the liver

摘要

According to some embodiments, a method of treating a subject having diabetes or symptoms associated with diabetes is provided. The method includes delivering a neuromodulation catheter within a vessel (e.g., hepatic artery) having surrounding nerves that innervate the liver (e.g., sympathetic nerves of the hepatic plexus). The method may also include modulating (e.g., disrupting, ablating, stimulating) the nerves by mechanical compression, energy delivery, or fluid delivery.

主权项

1. A method of facilitating hepatic neuromodulation in a subject, comprising:
positioning an energy delivery device at a location to deliver energy to sympathetic nerves that innervate a liver of the subject and delivering energy to the sympathetic nerves, using the energy delivery device, sufficient to ablate the sympathetic nerves in a manner that facilitates a reduction in at least one of a blood glucose level or a lipoprotein level in the subject, wherein the delivered energy is radiofrequency energy having a frequency between 50 kHz and 5 MHz, wherein the delivered energy heats the sympathetic nerves to a temperature of up to 90 degrees Celsius; and wherein the sympathetic nerves are sympathetic nerves of a hepatic plexus.