| 发明名称 | Method for using inactivated Japanese encephalitis virus particles as adjuvant | ||
| 摘要 | A method for using inactivated Japanese encephalitis virus particles as an adjuvant of a vaccine is provided. A method for using inactivated Japanese encephalitis virus (JEV) particles as an adjuvant of various vaccines or a mixed vaccine, said JEV particles being obtained by inoculating JEV Beijing-1 strain to Vero cells, culturing said JEV-infected cells to give cultured cells or culture supernatant, purifying JEV particles from said cultured cells or culture supernatant and inactivating said JEV particles with formalin, a method for preparing a (mixed) vaccine which comprises a step of letting inactivated Japanese encephalitis virus be contained, and a mixed vaccine prepared by said method. | ||
| 申请公布号 | US9114098(B2) | 申请公布日期 | 2015.08.25 |
| 申请号 | US200912996236 | 申请日期 | 2009.05.27 |
| 申请人 | THE CHEMO-SERO-THERAPEUTIC RESEARCH INSTITUTE | 发明人 | Moriyama Makoto;Kaminaka Kazuyoshi;Matsuda Junichi;Nozaki Chikateru |
| 分类号 | C07K14/18;A61K39/00 | 主分类号 | C07K14/18 |
| 代理机构 | Oblon, McClelland, Maier & Neustadt, L.L.P. | 代理人 | Oblon, McClelland, Maier & Neustadt, L.L.P. |
| 主权项 | 1. A method for preparing a vaccine, the method comprising: incorporating an inactivated Japanese encephalitis virus, obtained by culture of Vero cells, in the vaccine as an adjuvant wherein the inactived Japenese encephalitis virus is in particles which are present in concentration of 250 ng to 34 μg/mL, and wherein the vaccine is selected from the group consisting of diphtheria/pertussis/tetanus (DPT) vaccine, inactivated polio (IPV) vaccine, HepA vaccine and HepB vaccine. | ||
| 地址 | Kumamoto JP | ||