| 发明名称 | P16<sup>INK4A </sup>derived peptides for prophylaxis and therapy of HPV-associated tumors and other P16<sup>INK4A </sup>expressing tumors | ||
| 摘要 | Described are particular fragments of the cyclin-dependent kinase inhibitor p16 capable of increasing IFN-γ secretion of T cells or inducing proliferation of T cells and the use of said fragments for immunizing an individual against HPV-associated or other p16INK4a expressing carcinomas, preferably advanced carcinomas. | ||
| 申请公布号 | US9114101(B2) | 申请公布日期 | 2015.08.25 |
| 申请号 | US201213714273 | 申请日期 | 2012.12.13 |
| 申请人 | RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG | 发明人 | Kloor Matthias;Reuschenbach Miriam;Von Knebel-Doeberitz Magnus |
| 分类号 | C07K5/00;A61K39/00 | 主分类号 | C07K5/00 |
| 代理机构 | Perkins Coie LLP | 代理人 | Perkins Coie LLP ;Kung Viola T. |
| 主权项 | 1. A fragment of the cyclin-dependent kinase inhibitor p16INK4 capable of inducing an immune response against p16INK4a, consisting of (a) any one of the following amino acid sequences:(SEQ ID NO: 3)(1) LPNAPNSYGRRPIQVMMMGSARVAELL; (SEQ ID NO: 4)(2) VMMMGSARVAELLLLHGAEPNCADPATLTR; (SEQ ID NO: 5)(3) ADPATLTRPVHDAAREGFLDTLVVLHRAGARL; or (b) a combination of fragments of (a). | ||
| 地址 | Heidelberg DE | ||