System and method of increasing sample throughput by estimation of a sensor endpoint

摘要

Technologies for increasing sample throughput by predicting the end point response time of a sensor for the analysis of an analyte in a sample are disclosed. In one aspect, a system includes a sensor that generates data signals associated with the measurement of an analyte within the sample. A processor records appropriate data points corresponding to the signals, converts them to a logarithmic function of time scale, and plots the converted data points. The processor then determines a curve that fits the plotted data points and determines a curve fitting equation for the curve. Once the equation is determined, the processor extrapolates an end point response of the sensor using the equation. A value, such as analyte concentration, is then calculated using the extrapolated end point response.

主权项

1. A non-transitory computer storage medium storing an analyte concentration measurement application to increase sample throughput, the application comprising:
a sensor communication module that causes a processor to receive data signals from one or more sensors; a data point reporting module that causes the processor to capture and record data points from said data signals; a data point selection module that causes the processor to select predetermined data points from said data points; a curve fitting module that causes the processor to obtain a logarithmic function of time corresponding to the predetermined data points; the logarithmic function of time being obtained from a curve fitting equation of the form s(t)=a*(log(t))^2+b*log(t)+c, wherein t represents time, s(t) represents data point at time t, and a, b and c are fit parameters for a second order polynomial that are determined based on the predetermined data points; an extrapolation module that causes the processor to extrapolate an end point response of a sensor from the one or more sensors; a validation module that causes the processor to validate said end point response; and an analyte concentration reporting module that causes the processor to determine a concentration of an analyte within a sample using said end point response, thereby increasing sample throughput.