| 摘要 |
A method for controlling (e.g., inhibiting, activating, or up-regulating) various ion channels of cells includes contacting the cell with an effective amount of an aminosterol compound or a salt thereof. This contact can be provided, for example, by administering a pharmaceutical composition to a patient, wherein the pharmaceutical composition includes a pharmaceutically acceptable carrier or excipient, and at least one aminosterol compound. The method according to the invention can be used to treat, for example, ulcers (e.g., gastric ulcers or duodenal ulcers), cardiac arrhythmia, Sjögren's syndrome, cystic fibrosis, head trauma, constipation, post-menopausal dry mucosa syndrome, osteoporosis, or hypertension. |
