发明名称 Compuestos bicíclicos de urea, tiourea, guanidina y cianoguanidina; proceso de preparacion; composicion farmaceutica; útiles para el tratamiento del dolor y el cancer.
摘要 Compounds of Formula I: or stereoisomers, tautomers, or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein Ring A, Ring C and X are as defined herein, are inhibitors of TrkA kinase and are useful in the treatment of diseases which can be treated with a TrkA kinase inhibitor such as pain, cancer, inflammation/inflammatory diseases, neurodegenerative diseases, certain infectious diseases, Sjogren's syndrome, endometriosis, diabetic peripheral neuropathy, prostatitis and pelvic pain syndrome.
申请公布号 CL2015001282(A1) 申请公布日期 2015.08.21
申请号 CL20150001282 申请日期 2015.05.12
申请人 ARRAY BIOPHARMA, INC. 发明人 KERCHER TIMOTHY;ALLEN SHELLEY;JIANG YUTONG;WINSKI SHANNON L.;BRANDHUBER BARBARA J.;ANDREWS STEVEN WADE;BLAKE JAMES F.;HASS JULIA;KOLAKOWSKY GABRIELLE R.;THOMAS ALLEN A.
分类号 C07D401/14;A61K31/4155;A61K31/4162;A61P25/00;A61P35/00;C07D403/04;C07D405/12;C07D413/12;C07D453/02 主分类号 C07D401/14
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