METHODS OF TREATING A TAUOPATHY

摘要

The present disclosure provides methods of treating a tauopathy, involving administering an anti-Tau antibody. The present disclosure also provides anti-Tau antibodies, and formulations comprising same, for use in the methods.

主权项

1. An isolated nucleic acid comprising a nucleotide sequence encoding light chain variable region complementarity-determining regions (CDRs) 1, 2, and 3 of a humanized antibody that specifically binds an epitope within the N-terminal portion of a human Tau polypeptide, wherein the:
(i) VL CDR1 comprises the amino acid sequence of SEQ ID NO:1; (ii) VL CDR2 comprises the amino acid sequence of SEQ ID NO:2; and (iii) VL CDR3 comprises the amino acid sequence of SEQ ID NO:3.