发明名称 |
IMMUNOTHERAPY OF CANCER THROUGH COMBINATION OF LOCAL AND SYSTEMIC IMMUNE STIMULATION |
摘要 |
Provided herein are compositions and methods for immunotherapy of cancers, said methods combining systemic vaccination with a recombinant expression vector encoding a viral antigen and/or a cancer specific tumor antigen(s) to induce activated CD8 T-cells, with a local (e.g., intratumoral) immune stimulation using standard or modified application of a TLR agonist, to induce local inflammatory and innate immune responses which recruit T-cells to the tumor. |
申请公布号 |
WO2015123496(A1) |
申请公布日期 |
2015.08.20 |
申请号 |
WO2015US15767 |
申请日期 |
2015.02.13 |
申请人 |
IMMUNE DESIGN CORP. |
发明人 |
TER MEULEN, JAN, HENRIK;PAYA CUENCA, CARLOS, V. |
分类号 |
A61K39/00 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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